Should cases without suspects be submitted?

Yes, crime scene evidence DNA profiles can be entered into the Combined DNA Index System (CODIS) database (as long as they meet the eligibility requirements set forth by the FBI) and searched for investigative leads. When there is a CODIS hit to a subject, a letter will be sent to the investigator.  The investigator should collect a known reference sample (buccal swab) from that individual and submit it to the laboratory so comparisons can be made between the reference sample and evidence profiles.